CBD, short for Cannabidiol, is a natural compound that is one of the two primary constituents found in Cannabis. CBD is a safe, non-addictive substance, but is often confused or grouped in with Tetrahydrocannabidiol(THC) which is the more stigmatized and frequently associated component of cannabis that is psychoactively altering and produces the marijuana high.

cbd molecular structure

CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile. Phytocannabanoids work similarly to endocannabanoids, contained within our own body and are considered neurochemicals that are found throughout the nervous system and are connected to our immune response and even our reproductive system.
While both predominating cannabanoids have bountiful therapeutic effects, they communicate in very different ways with different receptors in the body and brain.

The Endocannabanoid System

CBD works with the Endocannabanoid System(ECS) in our body which is a regulatory infrastructure present in the brain and nervous system of mammals. The Endocannabinoid System is a network of cells throughout our body that have CBD receptors. The ECS permeates the 11 physiological systems in the body necessary for survival and ultimately helps cultivate homeostasis which is a stable internal environment. The ECS monitors and regulates the body’s constant struggle between building itself up(anabolism) and breaking itself down. (catabolism)

cbd impact on endocannabanoid system in body

The ECS is comprised of two receptors:

  • Cannabinoid-1(CB1)
  • Cannabinoid-2(CB2)

And two signalign molecules

  • Arachidonyl athanolamide (AEA)
  • 2-Arachidonyl Glycerol 2-AG